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Contraindications using somatotropin:
Hypersensitivity in certain patients to the product or any of its ingredients. Patients with complete knitting of the epiphyses. Diabetes mellitus. Somatotropin should not be used if there is any sign of active neoplasms. Endocrane lesions must be inactive and anti-tumoral treatment finished before beginning hormonal treatment. The use of somatotropin must be interrupted in the event of renewed tumoral growth.

Precautionary measures in the usage of somatotropin:
Somatotropin treatment should only be carried out under a doctor’s authorization, by university medical centers or hospitals specializing in the treatment of patients with growth hormone deficiency. Diagnoses must be confirmed before beginning Humatrope injections. This requires a clinical examination of the patient with detailed case histories, particularly with regard to auxilogical evaluations and the carrying out of laboratory tests, including stimulus test, to verify hypophysial hypothalamus functioning. G.H. therapy should be carried out by a specialist in the diagnosis and treatment of patients. Patients who, following diagnosis, undergo treatment with the somatotrophic hormone will have to be inscribed in a regional register and monitored by means of clinical auxilogical and laboratory evaluations every six months to check the functioning of the thyroid, glucide metabolism etc. The lack of available information may mean the exposure of the patient to a risk, which may exceed the therapeutic benefit obtained. Human hormone growth treatment should be complemented by an adequate supply of calories and amino acids. Once reconstituted with the accompanying diluent, h.g.h. can be taken in subcutaneous or intramuscular injections.

Interactions using somatotropin:
Since taking H.G.H. may cause resistance to insulin, patients should undergo periodic check ups in order to detect any intolerance to glucose. Children suffering from diabetes mellitus should be carefully supervised during treatment, as it may be necessary to increase their insulin dosage. Excessive glucocortoid treatments may inhibit the effect of growth stimulation provided by the human somatotrophic hormone. In the case of patients who also suffer from ACTH (adrenocrticotrophic hormone) deficiency, the substitutive dosage of glucocorticoids must be accurately regulated in order to prevent any inhibitory effect on growth.

Directions for reconstitution and administration of H.G.H.:
Do not reconstitute or administer this pharmaceutical product without first receiving adequate instructions as to the correct technique by the specialist. Follow the doctor’s sterilizing technique by the specialist. Follow the doctor’s sterilizing technique. Destroy and get rid of syringes or needles following each use. H.G.H. must be kept in a cool place (from +2 degrees Celsius to +8 degrees Celsius) after reconstitution (refrigerator). DO NOT FREEZE. ONCE RECONSTITUTED, SOMATOTROPIN MUST BE USED WITHIN 21 DAYS.

Reconstitution of the somatotropin bottle:
Reconstitute Humatrope only with diluent provided. Do not use any other solution for reconstitution unless it is by your doctor’s prescription. The doctor will also decide the correct sizes of the syringe and needle and the amount of diluent to add to the bottle. ALWAYS WASH YOUR HANDS FIRST
Remove and throw away the stoppers of the bottles of diluent and of somatotropin. Clean the rubber covering of the bottles with cotton wad soaked in alcohol (see figure 1 in pack). Remove the protective covering of the needle and set it aside. Pull the piston of the syringe until the same volume of air is let in as the volume of diluent prescribed by the doctor. Insert the needle into the rubber stopper of the bottle of diluent and inject air into the bottle.
Holding the bottle upside down and making sure that the needlepoint is in the solution, extract the amount of diluent prescribed by the specialist (see figure 2 in pack). Once you are sure there are no air bubbles left in the syringe, turn the bottle right side up and extract the syringe, taking care that the position of the piston does not change.
Insert the same needle into the bottle of Humatrope and gently turn the needle point inwards towards the side of the bottle. Slowly inject the diluent, directing the flow towards the side (see figure 3 in pack). DO NOT AIM IT IN THE DIRECTION OF THE WHITE POWDER AT THE BOTTOM OF THE BOTTLE. To balance the pressure and before removing the syringe from the bottle, let in a volume of air equal to that of the diluent just added. If the needle can become separated from the body of the syringe, remove, destroy and throw it away. If the needle and the syringe cannot be separated, eliminate the entire unit.
Shake the bottle with a gentle rotating movement until the contents are completely dissolved.

Preparing the injections:
Do not use, if upon reconstitution, it is opalescent or contains precipitates.
If the needle can be separated from the syringe, apply a new needle before giving the injection. If the syringe and needle from an inseparable unit use another syringe for the preparation of the injection.
Before and after administrating the injection, the rubber stopper of the bottle must be cleaned with alcohol or an alcohol based antiseptic solution to avoid that repeated insertions of the needle contaminate the contents.
Remove the cover of the needle and let an amount of air equal to the amount of somatotroipn into the syringe.
Insert the cover of the bottle of reconstituted somatotropin and inject air into the bottle. Turn the bottle upside down and making sure that the needlepoint is in the solution, inject the exact dosage. Make sure that there are no air bubbles in the syringe.
Remove the syringe and wrap up the needle. Write down the date of reconstitution on the label of the bottle and eliminate any diluent, which has not been used.
Put the unused part of reconstituted somatotropin in the refrigerator and use it within 21 days.
Destroy the needle or syringe needle unit once finished.

Overdose may cause hypoglycemia followed by hyperglycemia. Long term overdose may result in symptoms of acromegaly, similar to the effects of an excess of human somatotrophic hormone.